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Zahratul Aini
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INDONESIA
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Published by Universitas Islam Indonesia
ISSN : 20854145     EISSN : 25272950     DOI : 10.208885/JKKI.Vol10.Iss3.art5
Core Subject : Health,
Medicine & Pharmacology Public Health
JKKI: Jurnal Kedokteran dan Kesehatan Indonesia is a peer-reviewed journal in the field of medical and health sciences. This journal is designed as a place of dissemination of information and scientific knowledge, which publishes three times a year. It publishes original article, article review, and case report. These comprise of biomedical sciences, clinical medicine, public health sciences, and medical science education.
Arjuna Subject : Kedokteran - Kedokteran Keluarga
Articles 14 Documents
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Search results for , issue "JKKI, Vol 10, No 1, (2019)" : 14 Documents clear
HUBUNGAN MALNUTRISI DENGAN KEJADIAN STROKE Aditya Batlajery; Esdras Ardi Pramudita; Sugianto Sugianto; Rizaldy Taslim Pinzon
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art9

Abstract

Background: Stroke is a serious health problem that is characterized by high morbidity and mortality. One of the risk factors for stroke able to be controlled is malnutrition (undernutrition). Malnutrition can be assessed by Total Lymphocyte Count (TLC) if a low TLC value is found or less than 1500 cells/mm3. Undernutrition increases the risk of cerebrovascular disease. Lack of substances such as vitamins can affect brain blood vessels.Objective: To determine the relationship of malnutrition assessed according to the parameter of Total Lymphocyte Count (TLC) to stroke. Methods: This study used a cross-sectional research method. The sample was obtained from the medical record data of the patient in the nerve polyclinic at Bethesda Hospital, Yogyakarta. The sample size in this study was 210 medical records consisting of 105 stroke patients and 105 non-stroke patients. Data from medical records obtained were analyzed by computerization and tested by univariate analysis followed by bivariate analysis with chi-square test. Results: In this study, the description of sex showed that the majority were male patients by 119 (56.7%), while female patients were 91 (43.3%). The most age ranges in this study were aged 60-69 years and over 70 years, each of which was 64 (30.5%). The most common risk factor was hypertension with 131 patients (62.4%). In the statistical analysis it was found that hypertension showed a significant relationship (RP: 4.85, 95% CI: 2.62-8.97, p: 0.000), and it was the strongest variable related to stroke. Statistical malnutrition did not have a significant relationship to the incidence of stroke (Rp. 0.80, 95% CI: 0.32-2.00, p: 0.644).Conclusion: Generally, malnutrition does not show a significant relationship to stroke. Hypertension is an independent risk factor for stroke.
PERBEDAAN PERUBAHAN KADAR KOLESTEROL TOTAL DAN TRIGLISERID ANTARA PEMAKAIAN MONOTERAPI INSULIN DENGAN TERAPI KOMBINASI INSULIN DAN METFORMIN PADA PASIEN DIABETES MELITUS TIPE II Prita Murani Nugraheti; Erlina Marfianti; Linda Rosita
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art3

Abstract

Backround: Diabetes mellitus (DM) is a degenerative disease predicted by WHO to increase in Indonesia from 8.4 million in 2000 to around 21.3 million in 2030. Diabetes mellitus is closely related to dyslipidemia which can increase the risk of coronary artery disease (CAD). Current DM treatment is using oral hypoglycemic drugs, insulin, or a combination of both. Many previous studies have not examined the effect of these therapies on lipid profiles, specifically total cholesterol and triglyceride levels.Objective: To determine the differences in changes in total cholesterol and triglyceride levels between the use of insulin monotherapy and combination therapy of insulin and metformin in patients with type II diabetes mellitus in Sleman Yogyakarta Hospital from January 2010 toJune 2012.Methods: This study was an observational analytic study using a retrospective cohort study method with samples (n = 64). Samples were taken by non-probability consecutive sampling, carried out in DM patients inpatient or outpatient at Sleman Yogyakarta Hospital for the period of January 2010 - June 2012. The samples were divided into two groups, insulin monotherapy group and insulin and metformin combination therapy group. The data taken was the total cholesterol and the first triglyceride level, then the second total cholesterol and triglyceride data were made after four months of getting therapy.Result: Analysis of statistical data using the Mann Whitney test for changes in total cholesterol levels in the two treatment groups showed p = 0.166, whereas for changes in triglyceride levels in the two treatment groups it was found that p = 0.840.Conclusion: There were no significant differences in changes in total cholesterol and triglyceride levels between the two treatment groups.
Correlation between the effect of increasing body weight with plantar pressure and ankle-knee radiographic angle parameters changes Dimas Triaryo; Luthfi Hidayat; Rahadyan Magetsari
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art5

Abstract

Background: Understanding the biomechanical structure of the body is important to preventing and treating the musculoskeletal system problems. The increase in body mass index contributes to the elevated peak plantar pressure and decreased longitudinal arch of the foot. This condition, consequently, may cause mal-alignment of the lower extremity, leading to promote cartilage breakdown, osteophyte formation, subchondral bone hypertrophy, lead to progression of knee joint destruction and functional deficits. Objective: The aim of the study was to examine the correlation between body weight, plantar pressures, ankle and knee angle measurement parameters.Methods: The research study sample included 30 female who met inclusion and exclusion criteria. In order to evaluate the structural characteristic of plantar foot, we used the blueprint method on bare-foot and also when carrying 15 and 25 kilogram of load. Furthermore, to measure knee-angle parameters, we also performed a bilateral standing radiograph approach of lower extremity. Results: This study showed a significant correlation between BMI/Body mass index and HW/heel width (p = 0,00) with low positive correlation for both sides. Furthermore, BMI and PAW/plantar arch width (p = 0,00) showed a moderate positive correlation for both sides. In contrast to that, BMI and MFA/mid-foot area (p = 0,00) showed a moderate positive correlation for the right side but low positive correlation for the left side. Another measurement such as BMI and AI/arch index (p = 0,00) had a strong positive correlation on the right side and moderate positive correlation on the left side. Moreover, BMI and AAL/Ankle angle alignment (p = 0,00) revealed a strong positive correlation for both sides, BMI and XCTP/trans-condylar tibial plateau angle (p < 0,05) had a low positive correlation for both sides, meanwhile BMI and AA/ankle angle (p = 0,00) showed a low positive correlation for both sides. Conclusion: Increasing axial load was statistically significant correlated with increasing plantar pressure and ankle-knee radiographic angle parameter. The results also revealed that increasing axial load was found to have strong correlation to the arch index (AI) and ankle angle alignment (AAL). It was a compensatory phenomenon, which can cause structural disturbances and function of the lower limb.
Melioidosis and scrub typhus co-infection in a patient presenting with acute undifferentiated febrile illness Muhammad Yazli Yuhana; Ampai Tanganuchitcharnchai; Pimpan Sujariyakul; Piengchan Sonthayanon; Kesinee Chotivanich; Daniel H. Paris; Sasithon Pukrittayakamee; Stuart D. Blacksell; Borimas Hanboonkunupakarn
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art12

Abstract

Melioidosis and scrub typhus are endemic diseases in Malaysia. However, unlike melioidosis, scrub typhus is more difficult to be diagnosed and in Malaysia its true disease burden is unknown. We report a case of severe melioidosis and scrub typhus co-infection in a patient living in a small village in Peninsular Malaysia whom presented with fever and headache. This case highlights the importance of considering scrub typhus as a diagnostic possibility in cases of acute undifferentiated febrile illness in rural areas such as that of in Peninsular Malaysia.
Effect of concentration veriations exstract etanol salam leaves (eugenia polyantha wight) on risk free radicals dpph (1,1-diphenyl-2-picrylhydrazyl) Any Guntarti; Nurdiansyah Nurdiansyah
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art10

Abstract

Background: Salam leaves (Eugenia polyantha Wight) contains antioxidant compounds, flavonoids and polyphenols. These compounds are reported to inhibit oxidation activity by binding with free radicals. The unlimited amount of free radicals in the body will increase the risk of contracting degenerative diseases.Objective: The purpose of this study was to identify compounds from the ethanol extract of salam leaves and to test the antioxidant activity of its compounds using DPPH method and also determine the IC50 (Inhibition Concentration 50) of between the ethanol extract of salam leaves and quercetin standard. Methods: Ethanol concentration extract of salam leaves were obtained by maceration method with the ethanol solution. The compounds were identified by phytochemical screening. The concentration used for the extraction of salam leaves were 30%, 40% and 50%. The variations of each extract concentration were 50, 75, 100, 125 and 150 mg/mL. The variations of standard quercetin concentration were 1, 2, 3, 4 and 5 mg/mL. Antioxidant activity was tested by visible spectrophotometry using the DPPH method. The antioxidant activity is represented as the per cent of free radical scavenging and IC50. Results: The 30%, 40% and 50% ethanol extract of salam leaves contained flavonoid and polyphenol compounds, and also had free radical binding activity. The average value of IC50 quercetin, 30%, 40% and 50% ethanolic extract of salam leaves were 1.68, 102.48, 149.88 and 197.19 mg/mL.Conclusion: Statistical analysis showed that the antioxidant activity between quercetin, 30%, 40% and 50% ethanol extract of salam leaves were significantly different (P=95%). 
Adopting Mass Thalassemia Prevention Program in Indonesia: a Proposal Lantip Rujito; Joko Mulyanto
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art1

Abstract

No Abstract
DISTRIBUSI DAN DETERMINAN HIPERTENSI DI KECAMATAN SAMBIREJO, KABUPATEN SRAGEN Pariawan Lutfi Ghazali
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art6

Abstract

Background: One of the most prevalent degenerative diseases is hypertension. The statistic data of Sambirejo sub-district of Sragen Regency shows that hypertension is the disease with the second largest number of patients. Research on the distribution and determinant of hypertension needs to be done to support intervention efforts.Objective: This study aims to determine the distribution and determinants of hypertension in Sambirejo sub-district, Sragen Regency.Methods: This observational study used a cross-sectional design, with descriptive analytic types. The sample was taken using a stratified random sampling technique. Blood pressure measurements using sphygmomanometer, and other data obtained from questionnaires and direct measurements. We tested the relationship between variables with Kruskal-Wallis bivariate analysis. The multivariate analysis used is Ordinal Regression. Data were statistically significant if p <0.05 (CI: 95%).Results: The study sample was 454 people. Respondents who experienced hypertension were very high at 57.2%. Hypertension is more prevalent in men, and ages 40 and above. Determinant factors of hypertension are age, gender, genetics, exercise habits, smoking habits, fruit and vegetable consumption, and body mass index. Multivariate analysis with ordinal regression test showed the factors to influence the hypertension were genetic factors (OR=4,777; 95% CI 3,232-7,059; p=0,000), smoking (OR=1,004, 95%CI: 1,003 – 1,004, p=0,0001), and body mass index. (OR=1,054; 95%CI:1,002 – 1,109, p=0,042).Conclusion: Hypertension distribution is more dominant in the male group, and =40 years of age. Determinants of hypertension are age, sex, genetics, exercise habits, smoking habits, fruit and vegetable consumption, and body mass index. Genetic factors are the dominant determinant for hypertention.
The relationship between duration suffering diabetes mellitus and hearing threshold based on audiometric examination Bambang Udji Djoko Rianto; Heri Puryanto; Kartono Sudarman
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art7

Abstract

Background: Chronic hyperglycemia is associated with a long term damage, dysfunction or failure of several organs, which is a degenerative disorder caused by persistent hyperglycemia. Complications also can cause interference with the threshold of hearing. These degenerative changes include atrophy of axons, demyelinization, and loss of nerve fibers.Objective: This study aimed to determine the relationship between long suffering diabetes mellitus and hearing thresholds based on its frequency. Methods: This study was a cross sectional design on patients with diabetes mellitus in the Internal Medicine Clinic and Otorhinolaryngology Department Dr. Sardjito General Hospital Yogyakarta from early November 2010 until the end of June 2011. Inclusion criterion were: 1) >50 years old 2) normal physical ENT examination, 3) all DM types, 4) Sensorineural (Perceptive) Hearing Loss, 5) Right and left ear gap audiogram less than 15dB, and 6) agreed to participate. Mean difference such as age and duration of DM were assessed by using independent t test and Mann Whitney test. Distribution of sex and educational level were assessed by using Chi square test and Fisher's Exact test. Correlation between duration suffering diabetes mellitus and hearing threshold was assessed by the Spearman and Pearson method. Results: Subjects participated in this research were 25 (41.7%) men and 35 (58.3%) women. Result of this study showed that there were correlation between long suffering DM and hearing thresholds at 2000Hz : (r=0.459, p=0.097), 4000Hz (r=0.4966, p=0.098), and 6000Hz (r=0.757, p=0.422), respectively.Conclusion: It is can be concluded that there is a positive correlation between long suffering DM and hearing threshold, especially after 6 years.
Chemical compounds and antibacterial activity of Garcinia dulcis (Roxb)kurz. Hady Anshory Tamhid
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art11

Abstract

Garcinia dulcis is a medicinal plant used traditionally to treat various diseases including infections of wounds and ulcers. The antibacterial activity of this plant has also been widely reported, but the most potent compounds as an antibacterial agent are not widely reported, even though the compounds contained in this plant is well known. This paper reviews the compounds contained in G. dulcis plants and their potential as antibacterial agents. Each part of this plant, such as leaves, fruits, flowers, seeds, stems, and roots, contains secondary metabolites which are potential antibacterial agents. Here are described the compounds contained in each part of the plant, such as xanthones, the most dominant compounds, then flavonoids, benzophenones, chromones, and triterpenoid. Their antibacterial activity is also described, especially those that have strong activity against bacteria. The molecular structure and the possibilities of how the antibacterial mechanism are also discussed.  Eleven compounds that have the potential to be used as antibacterial agents for the treatment of infectious diseases. Garcigerin A (27) and a-mangostin (54) are compounds that have the most vigorous activity against S. aureus and MRSA compared to the other compounds. The Compounds that have strong activity can be used as antibacterial agents for anti-infective therapy, although they must go through various further studies.
Japanese Encephalitis Asri Hendrawati
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 10, No 1, (2019)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol10.Iss1.art2

Abstract

No Abstract

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